Predictors of Infliximab Clearance. Increased body weight, increased ADA concentrations, decreased serum albumin concentrations, and increased CRP or serum glucose concentrations were each predictive of higher baseline infliximab clearance (Figure 1).Over the range of body weight in the database (34–139 kg), baseline clearance ranged from 0.16 to 0.43 L/day.

tween fecal and serum concentrations of infliximab. CONCLU- weeks of treatment, IFX was detectable in feces of 25 of 30 patients (83%) and in 129 of 195

An undetectable trough serum infliximab, irrespective of antibody status, is associated with less favourable outcomes. The therapeutic strategy for … In a study of 115 patients with UC treated with 3 doses of infliximab induction followed by scheduled maintenance dosing, patients with detectable serum infliximab levels had higher rates of remission (69% vs 15%; P<.001) and endoscopic improvement (76% vs 28%; P<.001) than patients with undetectable infliximab levels. 13 An undetectable infliximab level predicted an increased risk for Infliximab Level and Anti-drug Antibody for IBD - When treatment of inflammatory bowel disease with infliximab or its biosimilar fails, a physician may need to consider treatment options, such as adjusting dose or dosing intervals, switching to a different TNF blocker, or switching to a non-TNF blocker. This test (1) measures infliximab and infliximab-dyyb (inflectra) levels to help 2015-02-24 (a) Clinical outcomes according to antibody to infliximab status. 24 In patients with inconclusive antibody status, clinical remission and endoscopic improvement occurred more frequently, while colectomy occurred less frequently than in patients with positive or negative antibodies.

Detectable serum infliximab

In a study of 115 patients with UC treated with 3 doses of infliximab induction followed by scheduled maintenance dosing, patients with detectable serum infliximab levels had higher rates of remission (69% vs 15%; P<.001) and endoscopic improvement (76% vs 28%; P<.001) than patients with undetectable infliximab levels. 13 An undetectable infliximab level predicted an increased risk for An undetectable trough serum infliximab, irrespective of antibody status, is associated with less favourable outcomes … For patients with ulcerative colitis treated with infliximab, a detectable trough serum infliximab predicts clinical remission, endoscopic improvement and a lower risk for colectomy. Background: Anti-infliximab antibodies (ATIs) are associated with lower serum infliximab (IFX) trough levels and diminished clinical response. The current most prevalent method for detection of ATI is a double-antigen (DA) enzyme-linked immunosorbent assay (ELISA) utilizing IFX for ligand and detection antibody. A detectable trough serum infliximab was also associated with a lower C-reactive protein (2.0 vs 11.8 mug/L; P < .001) and a higher rate of endoscopic improvement (88% vs 33%; P < .001). Concurrent immunomodulators did not alter outcomes.

RTX was detectable in the serum of patients 3 - 6 months after RA that had inadequate response to anti-TNF regimens and > 79% were. with enthesitis-related arthritis had highest serum sRAGE (1552.

Ito, Komei. The predictive relationship between peanut- and Ara h 2-specific serum IgE IgG4 anti-infliximab in treated patients: Clinical impact and temporal

av A Rydén · 2011 — might be detected in connection with trauma, circulatory stress or acute infections. the serum and other body fluids, and their function is to bind invading anti-TNF-α during the same time period completely prevented diabetes during the. RTX was detectable in the serum of patients 3 - 6 months after RA that had inadequate response to anti-TNF regimens and > 79% were.

Patients with detectable pre-infusion anti-infliximab antibodies have significantly more often low/no infliximab levels (< 1 mg/l) halfway trough the infusion cycle (in 5/7 patients) compared to patients without detectable pre-infusion anti-infliximab antibodies (0/20 patients, p < 0.001).

Ann Rheum Dis 2009;68:1739–1745. Seow CH et al. Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis.

Infliximab ADA formation is defined as any detectable amount of ADA in the absence of detectable serum infliximab (measured by enzyme-linked immunosorbent assay, ELISA). Secondary Outcome Measures : Infliximab levels were measured by ELISA (lowest detectable level = 0.1 μg/ml). Modeling serum profiles for each of the dosing regimens were used to determine the benefit of a dose increase versus a change in dosing interval frequency to achieve adequate clinical response. Results: If infliximab level is sub-therapeutic and total infliximab anti-drug antibody is detected: Detectable serum infliximab anti-drug antibody may cause accelerated infliximab clearance leading to reduced trough levels and a compromised clinical response.
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In all, 16/76 patients (22.4%) presented detectable infliximab antibodies in the serum. Ten antibody-positive patients had an intensification of infliximab therapy and six (60%) demonstrated a clinical response.

There was a high correlation between the 2 methods for ATI levels (p<0.001).
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2 mL serum collected in a red-top tube (no gel) Minimum Volume. 1 mL. Collection Instructions. The blood should be drawn just before the next infusion of infliximab to measure the trough drug level. Transport Container. Transport tube. Transport Temperature. Refrigerated (cold packs) Specimen Stability. Room temperature: 48 hours ; Refrigerated: 7 days

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